NEW Source, November 1991 Page: 1
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NEW.u
A monthly publication of The PWA Health Group of Texas, Inc.
News For Toxo/MAI/Crypto Sufferers!
Azithromycin is the new kid on the block
by Matt EarnestMacrolide antibiotics have always been high
on the list when it comes to HIV research,
primarily because of their high degree of fat
solubility. This allows them to penetrate cells and
remain for considerably longer than some other
antibiotics. Azithromycin is in the macrolide
family, along with clarithromycin, erythromycin,
and roxithromycin, and appears to have promising
effects against MAC (MAI), toxoplasmosis,
cryptosporidium, and other minor infections.
Depending on the dose, Azithromycin has
demonstrated an intracellular half-life of
anywhere from 5-11 hours, and a beneficial blood
concentration from 1.5 to 3.3 hours after oral
administration. Because of this affinity for the
tissues, Azithromycin has a tendency to remain
with its cell until it reaches the site of infection,
where it spills out and assists the cell against the
bacteria.
Azithromycin's wide target area also gives it a
somewhat bright future in the field of AIDS
research. A steady amount of Azithromycin
appeared to decrease the number of organisms in
patients with MAC in a recent study at the Kuzell
Institute of San Francisco (9/91), which increased
when the medication was halted. Denny Smith of
AIDS Treatment News gave an anecdotal report of
a man rendered comatose by a toxoplasmic brain
lesion, and after one week of considerably large
doses of azithromycin (1 gram, then 500 mg dailyfor maintenance), "a CT (computerized
tomography) scan showed no signs of a lesion,"
and consciousness was restored.
Azithromycin has been approved in
Yugoslavia and Czechoslovakia for several years
for gonorrhea and chlamydia, and Dr. Bruni of
Washington D.C., among other physicians focused
primarily on AIDS/HIV, has advocated its use
against cryptosporidium for quite some time, as is
widely known.
see Azithrornycin, page 7
iCo1-enzyme 010 I ""November 1991
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Dallas Buyer's Club. NEW Source, November 1991, periodical, November 1991; Dallas, Texas. (https://texashistory.unt.edu/ark:/67531/metadc271478/m1/1/: accessed June 6, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu.; crediting UNT Libraries Special Collections.